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The Mad Crapper
03-21-2011, 08:31 AM
Scientists create animals that are part-human
Stem cell experiments leading to genetic mixing of species

RENO, Nev. — On a farm about six miles outside this gambling town, Jason Chamberlain looks over a flock of about 50 smelly sheep, many of them possessing partially human livers, hearts, brains and other organs.

The University of Nevada-Reno researcher talks matter-of-factly about his plans to euthanize one of the pregnant sheep in a nearby lab. He can’t wait to examine the effects of the human cells he had injected into the fetus’ brain about two months ago.

“It’s mice on a large scale,” Chamberlain says with a shrug.

As strange as his work may sound, it falls firmly within the new ethics guidelines the influential National Academies issued this past week for stem cell research.

In fact, the Academies’ report endorses research that co-mingles human and animal tissue as vital to ensuring that experimental drugs and new tissue replacement therapies are safe for people.

Doctors have transplanted pig valves into human hearts for years, and scientists have injected human cells into lab animals for even longer.

But the biological co-mingling of animal and human is now evolving into even more exotic and unsettling mixes of species, evoking the Greek myth of the monstrous chimera, which was part lion, part goat and part serpent.

In the past two years, scientists have created pigs with human blood, fused rabbit eggs with human DNA and injected human stem cells to make paralyzed mice walk.

Particularly worrisome to some scientists are the nightmare scenarios that could arise from the mixing of brain cells: What if a human mind somehow got trapped inside a sheep’s head?

The “idea that human neuronal cells might participate in 'higher
order' brain functions in a nonhuman animal, however unlikely that may be, raises concerns that need to be considered,” the academies report warned.

In January, an informal ethics committee at Stanford University endorsed a proposal to create mice with brains nearly completely made of human brain cells. Stem cell scientist Irving Weissman said his experiment could provide unparalleled insight into how the human brain develops and how degenerative brain diseases like Parkinson’s progress.

Stanford law professor Hank Greely, who chaired the ethics committee, said the board was satisfied that the size and shape of the mouse brain would prevent the human cells from creating any traits of humanity. Just in case, Greely said, the committee recommended closely monitoring the mice’s behavior and immediately killing any that display human-like behavior.

The Academies’ report recommends that each institution involved in stem cell research create a formal, standing committee to specifically oversee the work, including experiments that mix human and animal cells.

Weissman, who has already created mice with 1 percent human brain cells, said he has no immediate plans to make mostly human mouse brains, but wanted to get ethical clearance in any case. A formal Stanford committee that oversees research at the university would also need to authorize the experiment.

Few human-animal hybrids are as advanced as the sheep created by another stem cell scientist, Esmail Zanjani, and his team at the University of Nevada-Reno. They want to one day turn sheep into living factories for human organs and tissues and along the way create cutting-edge lab animals to more effectively test experimental drugs.

Zanjani is most optimistic about the sheep that grow partially human livers after human stem cells are injected into them while they are still in the womb. Most of the adult sheep in his experiment contain about 10 percent human liver cells, though a few have as much as 40 percent, Zanjani said.

Because the human liver regenerates, the research raises the possibility of transplanting partial organs into people whose livers are failing.

Zanjani must first ensure no animal diseases would be passed on to patients. He also must find an efficient way to completely separate the human and sheep cells, a tough task because the human cells aren’t clumped together but are rather spread throughout the sheep’s liver.

Zanjani and other stem cell scientists defend their research and insist they aren’t creating monsters — or anything remotely human.

“We haven’t seen them act as anything but sheep,” Zanjani said.

Zanjani’s goals are many years from being realized.

He’s also had trouble raising funds, and the U.S. Department of Agriculture is investigating the university over allegations made by another researcher that the school mishandled its research sheep. Zanjani declined to comment on that matter, and university officials have stood by their practices.

Allegations about the proper treatment of lab animals may take on strange new meanings as scientists work their way up the evolutionary chart. First, human stem cells were injected into bacteria, then mice and now sheep. Such research blurs biological divisions between species that couldn’t until now be breached.

Drawing ethical boundaries that no research appears to have crossed yet, the Academies recommend a prohibition on mixing human stem cells with embryos from monkeys and other primates. But even that policy recommendation isn’t tough enough for some researchers.

“The boundary is going to push further into larger animals,” New York Medical College professor Stuart Newman said. “That’s just asking for trouble.”

Newman and anti-biotechnology activist Jeremy Rifkin have been tracking this issue for the last decade and were behind a rather creative assault on both interspecies mixing and the government’s policy of patenting individual human genes and other living matter.

Years ago, the two applied for a patent for what they called a “humanzee,” a hypothetical — but very possible — creation that was half human and chimp.

The U.S. Patent and Trademark Office finally denied their application this year, ruling that the proposed invention was too human: Constitutional prohibitions against slavery prevents the patenting of people.

Newman and Rifkin were delighted, since they never intended to create the creature and instead wanted to use their application to protest what they see as science and commerce turning people into commodities.

And that’s a point, Newman warns, that stem scientists are edging closer to every day: “Once you are on the slope, you tend to move down it.”

© 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

http://www.msnbc.msn.com/id/7681252/ns/health-cloning_and_stem_cells

Rooster
03-21-2011, 08:34 AM
I've seen this movie. It ends badly.

JD10367
03-21-2011, 08:37 AM
I've seen this movie. It ends badly.

Yeah, I think I have too. It involves run-down buildings, things jumping out, lots of munching on limbs, lots of groaning and shuffling, and I think Bruce Campbell was in it.

blaise
03-21-2011, 08:44 AM
Rosie O'Donnell is half human and half pig.

BigCatDaddy
03-21-2011, 08:46 AM
Sweet. More talking Jack Asses.

Chromatic
03-21-2011, 08:51 AM
Awesome. I wanna see a Great White Shark-Eagle.

seclark
03-21-2011, 08:59 AM
i never injected that sheep...i was just helping it over the fence.
sec

MOhillbilly
03-21-2011, 09:20 AM
x2 except its head was stuck in the wire! swear!

Fish
03-21-2011, 09:26 AM
Nice scare article full of exaggerations and misconceptions.....

Rausch
03-21-2011, 09:26 AM
Nice scare article full of exaggerations and misconceptions.....

This...

Nzoner
03-21-2011, 09:31 AM
Let me guess they have a huge government grant of cash that could be going towards other things,say helping small businesses.



No,I did not read the entire article

Dave Lane
03-21-2011, 09:42 AM
Almost everything is part human. Learn a little science, jeez. 98.4% of chimp DNA is a perfect match for human DNA. There are greater DNA differences between varieties of Corn than there is differences between primates and humans.

Seriously does anywhere have a science editor any more?

Bowser
03-21-2011, 09:47 AM
Now, we are TRULY fucked.

http://www.2flashgames.com/2fgkjn134kjlh1cfn81vc34/flash/f-We-Are-Doomed-8268.jpg

CoMoChief
03-21-2011, 09:49 AM
Finally we can really live in a society where T-Rex's can fly fighter jets.

Guess now we just have to find a way to re-create the T-Rex

SNR
03-21-2011, 09:56 AM
Almost everything is part human. Learn a little science, jeez. 98.4% of chimp DNA is a perfect match for human DNA. There are greater DNA differences between varieties of Corn than there is differences between primates and humans.

Seriously does anywhere have a science editor any more?No. Data died at the end of Nemesis

Mr. Laz
03-21-2011, 10:11 AM
Forget about nukes, this is the shit that is eventually going to kill us all.

we aren't smart enough or discipline enough to screw with genetics without fucking shit up.

Dave Lane
03-21-2011, 10:13 AM
Forget about nukes, this is the shit that is eventually going to kill us all.

we aren't smart enough or discipline enough to screw with genetics without ****ing shit up.

So you've changed your mind about unions then I take it?

Fish
03-21-2011, 10:18 AM
It should be rather obvious that the article is written by a retard, when the first sentence of a supposedly scientific article describes the sheep as "smelly".

The Mad Crapper
03-21-2011, 12:16 PM
Nice scare article full of exaggerations and misconceptions.....

This...

Almost everything is part human. Learn a little science, jeez. 98.4% of chimp DNA is a perfect match for human DNA. There are greater DNA differences between varieties of Corn than there is differences between primates and humans.

Seriously does anywhere have a science editor any more?

http://www.militaryimages.net/photopost/data/576/11hitler_youth_02.jpg

Bump
03-21-2011, 12:18 PM
Let me guess they have a huge government grant of cash that could be going towards other things,say helping small businesses.



No,I did not read the entire article

helping small businesses? LOL, this country aims to destroy small businesses. That would never happen man, sorry.

Bowser
03-21-2011, 12:18 PM
Didn't the Nazi's try to make some half human, half grizzly bear soldier back in the day? Or am I thinking of a really bad video game/movie?

FAX
03-21-2011, 12:26 PM
Didn't the Nazi's try to make some half human, half grizzly bear soldier back in the day? Or am I thinking of a really bad video game/movie?

Yes, they did, Mr. Bowser. They called these horrible monstrosities Bedeutengrubemachtiggrizzlytragens. But, they had to abandon the experiment because nobody could pronounce it.

FAX

The Mad Crapper
03-21-2011, 12:37 PM
Didn't the Nazi's try to make some half human, half grizzly bear soldier back in the day? Or am I thinking of a really bad video game/movie?

The Nazi's also had a plot to destroy us by counterfeiting our currency. It only took 66 years, but the US Treasury is doing it for them.

LMAO

sedated
03-21-2011, 01:15 PM
<img src="http://spfans.org/img/episodeguide/1205_snap1.jpg">

bevischief
03-21-2011, 01:30 PM
<img src="http://spfans.org/img/episodeguide/1205_snap1.jpg">

ROFL

mikey23545
03-21-2011, 01:42 PM
So you've changed your mind about unions then I take it?

The sheep with partly human brains should make great union workers (as well as democrats)...

Rooster
03-21-2011, 01:58 PM
If they start making swine with human hands Hog Farmer might be out of a job.:hmmm:

chasedude
03-21-2011, 03:59 PM
I would like to see a reverse to this study...

Inject humans with horse stem cells, I want a horse cock!

CrazyPhuD
03-21-2011, 04:46 PM
Hasn't the Westboro Baptist Church been doing this for years?

The Mad Crapper
03-29-2011, 10:57 AM
A pro-life group that monitors the use of cells from babies victimized by abortions is today bashing the biotech company Senomyx, which it says produces artificial flavor enhancers using aborted fetal cell lines to test their products.

The group Children of God for Life is calling for a public boycott of major food companies partnering with Senomyx.

Debi Vinnedge, the director of the pro-life organization, tells LifeNews.com today that, in 2010, her group wrote to Senomyx CEO Kent Snyder and pointed out that moral options for testing their food additives could and should be used. But when Senomyx ignored her letter, the group wrote to the companies Senomyx listed on their website as “collaborators” warning them of public backlash and threatened boycott. They included food giants PepsiCo, Kraft Foods, Campbell Soup, Solae and Nestlé. (See update below.)

“The company’s key flavor programs focus on the discovery and development of savory, sweet and salt flavor ingredients that are intended to allow for the reduction of MSG, sugar and salt in food and beverage products,” the Senomyx web site says. “Using isolated human taste receptors, we created proprietary taste receptor-based assay systems that provide a biochemical or electronic readout when a flavor ingredient interacts with the receptor.”

Vinnedge says a boycott is important because the collaborating companies provide Senomyx with research and development funding plus royalties on sales of products using their flavor ingredients.

“What they don’t tell the public is that they are using HEK 293 – human embryonic kidney cells taken from an electively aborted baby to produce those receptors,” she said. “They could have easily chosen animal, insect, or other morally obtained human cells expressing the G protein for taste receptors.”

Vinnedge says she has contacted the food companies working with Senomyx, but said it took three letters before one company, Nestlé, finally admitted its relationship with Senomyx and company officials claimed the line of cells from abortions was “well established in scientific research”.

http://www.lifenews.com/2011/03/29/company-uses-fetal-cells-from-abortions-for-artificial-flavors/

http://www.iaza.com/work/110330C/iaza17433192120700.jpg

Dave Lane
03-29-2011, 11:00 AM
Actually you are proof that abortion should be legal and liberally used. In your case I even approve of retroactive abortion.

Saulbadguy
03-29-2011, 11:07 AM
Mad Crapper needs a bullet in his skull.

Jaric
03-29-2011, 11:41 AM
Soylent Green!