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KILLER_CLOWN
05-12-2011, 01:04 AM
Toxin from GM crops found in human blood: Study
Posted on May 12, 2011 by pjwalker911| Leave a comment

indiatoday.intoday.in | May 11, 2011

by Dinesh C. Sharma

New Delhi – Fresh doubts have arisen about the safety of genetically modified crops, with a new study reporting presence of Bt toxin, used widely in GM crops, in human blood for the first time.

Genetically modified crops include genes extracted from bacteria to make them resistant to pest attacks.

These genes make crops toxic to pests but are claimed to pose no danger to the environment and human health. Genetically modified brinjal, whose commercial release was stopped a year ago, has a toxin derived from a soil bacterium called Bacillus thuringiensis ( Bt).

Till now, scientists and multinational corporations promoting GM crops have maintained that Bt toxin poses no danger to human health as the protein breaks down in the human gut. But the presence of this toxin in human blood shows that this does not happen.

Scientists from the University of Sherbrooke, Canada, have detected the insecticidal protein, Cry1Ab, circulating in the blood of pregnant as well as non-pregnant women.

They have also detected the toxin in fetal blood, implying it could pass on to the next generation. The research paper has been peer-reviewed and accepted for publication in the journal Reproductive Toxicology. The study covered 30 pregnant women and 39 women who had come for tubectomy at the Centre Hospitalier Universitaire de Sherbrooke (CHUS) in Quebec.

None of them had worked or lived with a spouse working in contact with pesticides.

They were all consuming typical Canadian diet that included GM foods such as soybeans, corn and potatoes. Blood samples were taken before delivery for pregnant women and at tubal ligation for non-pregnant women. Umbilical cord blood sampling was done after birth.

Cry1Ab toxin was detected in 93 per cent and 80 per cent of maternal and fetal blood samples, respectively and in 69 per cent of tested blood samples from non-pregnant women. Earlier studies had found trace amounts of the Cry1Ab toxin in gastrointestinal contents of livestock fed on GM corn. This gave rise to fears that the toxins may not be effectively eliminated in humans and there may be a high risk of exposure through consumption of contaminated meat.

“Generated data will help regulatory agencies responsible for the protection of human health to make better decisions”, noted researchers Aziz Aris and Samuel Leblanc.

Given the potential toxicity of these environmental pollutants and the fragility of the foetus, more studies are needed, particularly those using the placental transfer approach, they added Experts have warned of serious implications for India. Cottonseed oil is made from seeds of genetically modified cotton and thus Bt toxin may have already entered the food chain in India.

“Indian regulators should be immediately called for detailed toxicological studies to know the extent of contamination of the human blood with Bt toxins coming from cottonseed oil, and also ascertain its long term health impacts,” Sharma said.

http://aftermathnews.wordpress.com/2011/05/12/toxin-from-gm-crops-found-in-human-blood-study/

ClevelandBronco
05-12-2011, 01:59 AM
Maybe this will keep the mosquitos from biting.

Ebolapox
05-12-2011, 02:36 AM
nowhere does this mention ANYTHING microbiologically relevant. ok, it may be in the fetal blood. HOWEVER, the way ALL toxins work (and bacteria/viruses for that matter) is via specificity of receptor proteins on the surface of cells. the BT toxin has specificity for arthropod (specific insects for specific BT toxin type) gut epithelial cells. NOT, I repeat, NOT any mammalian cells. it's like cellulose. you eat it every day, but your cells can't do anything with it, so it doesn't enter your cells or harm anything. it just passes through your system without having a single effect.

so, is it possible that it persists in the GM food? sure. should we have a few more studies (believe me, they've been tested on mammalian cells. no harm in over 25 years of research) to shut up the idiots who've never taken a science class and/or don't know how to do a quick googlescholar or pubmed search? I guess. but should we be concerned? not in the least.

OMGZ, SCIENCE IS DA DEBBIL! RUN AND HIDE!

teedubya
05-12-2011, 03:30 AM
Shut up and eat your frankenstein food, Mr. KILLER CLOWN

mikey23545
05-12-2011, 04:38 AM
nowhere does this mention ANYTHING microbiologically relevant. ok, it may be in the fetal blood. HOWEVER, the way ALL toxins work (and bacteria/viruses for that matter) is via specificity of receptor proteins on the surface of cells. the BT toxin has specificity for arthropod (specific insects for specific BT toxin type) gut epithelial cells. NOT, I repeat, NOT any mammalian cells. it's like cellulose. you eat it every day, but your cells can't do anything with it, so it doesn't enter your cells or harm anything. it just passes through your system without having a single effect.

so, is it possible that it persists in the GM food? sure. should we have a few more studies (believe me, they've been tested on mammalian cells. no harm in over 25 years of research) to shut up the idiots who've never taken a science class and/or don't know how to do a quick googlescholar or pubmed search? I guess. but should we be concerned? not in the least.

OMGZ, SCIENCE IS DA DEBBIL! RUN AND HIDE!

This X 1000...

(this means I agree very strongly with this post, just so the kind of people who panic over these kinds of articles can follow along)

HonestChieffan
05-12-2011, 06:59 AM
Weeze all gunna dye

KILLER_CLOWN
05-12-2011, 08:09 AM
Weeze all gunna dye

Obvious answer is obvious.

KILLER_CLOWN
05-12-2011, 08:56 AM
ok, it may be in the fetal blood.

This is relevant, the rest is conjecture.

Ebolapox
05-12-2011, 09:40 AM
This is relevant, the rest is conjecture.

do yourself a favor and, instead of acting the role of chicken little so often, EDUCATE YOURSELF. if possible, take a bio course or two (specifically the one 'for science majors') at the local community college. there is absolutely no conjecture there; go look into the literature. the BT toxin is one of the most studied biological toxins (in some ways, more studied than the shigella and/or botulinum toxin); you can't dream up a study analyzing the relationship between the BT toxin and mammalian cells (remember: WE'RE MAMMALS) that hasn't been done/analyzed.

HonestChieffan
05-12-2011, 09:41 AM
Bt is non toxic. The LD 50 is not calculable.


Who makes this crazy shit up?


More evidence we need thought control helmets

Ebolapox
05-12-2011, 09:53 AM
Bt is non toxic. The LD 50 is not calculable.


Who makes this crazy shit up?


More evidence we need thought control helmets

you'd be shocked at the amount of people who (even if they've had a high school biology class) know absolutely NOTHING about science and consider it magic (they won't call it that, but there's a certain mysticism that the uneducated hold for biology/science).

it really is a shame, because issues like this are amplified when you have a bunch of herp-a-derps running around freaking out and they, in turn, drag other people into their web of freakout.

Chiefnj2
05-12-2011, 09:58 AM
nowhere does this mention ANYTHING microbiologically relevant. ok, it may be in the fetal blood. HOWEVER, the way ALL toxins work (and bacteria/viruses for that matter) is via specificity of receptor proteins on the surface of cells. the BT toxin has specificity for arthropod (specific insects for specific BT toxin type) gut epithelial cells. NOT, I repeat, NOT any mammalian cells. it's like cellulose. you eat it every day, but your cells can't do anything with it, so it doesn't enter your cells or harm anything. it just passes through your system without having a single effect.

so, is it possible that it persists in the GM food? sure. should we have a few more studies (believe me, they've been tested on mammalian cells. no harm in over 25 years of research) to shut up the idiots who've never taken a science class and/or don't know how to do a quick googlescholar or pubmed search? I guess. but should we be concerned? not in the least.

OMGZ, SCIENCE IS DA DEBBIL! RUN AND HIDE!

As a scientific rebuttal:

NOTE: GM lobbyists are claiming it doesn't matter if the Bt toxin is turning up in people's blood because the Bt toxin is natural, known to be harmless to humans, and has been safely used for decades in agriculture in the form of natural insecticidal sprays, including in organic farming. In addition, they say, Bt crops have been tested and approved as safe.

But the Bt toxin produced in GM crops is not the same as the natural Bt toxin. The process of genetic engineering changes it. And testing is not actually performed on the Bt toxin extracted from GM plants, which would be the scientific way, as it is claimed that it is too expensive to isolate.

GM Bt toxins are engineered into plants with promoters designed to keep the Bt toxin protein expressing in every cell of the plant. The Bt is ingested by animals and people who consume crop plants like Bt maize. The natural Bt used in agricultural sprays, by contrast, degrades rapidly in daylight and does not end up being eaten by people, so it is unlikely to ever end up in consumers' bodies.

This is fortunate because even natural Bt can cause harm when ingested. Studies show that it has ill effects on laboratory animals, producing a potent immune response and enhancing the immune response to other substances.

Vázquez RI, Moreno-Fierros L, Neri-Bazan L, De La Riva GA, Lopez-Revilla R. Bacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant. Scand J Immunol. Jun 1999;49(6):578-584.

Vázquez-Padrón RI, Moreno-Fierros L, Neri-Bazan L, de la Riva GA, Lopez-Revilla R. Intragastric and intraperitoneal administration of Cry1Ac protoxin from Bacillus thuringiensis induces systemic and mucosal antibody responses in mice. Life Sci. 1999;64(21):1897-1912.

Vázquez-Padrón RI, Moreno-Fierros L, Neri-Bazan L, Martinez-Gil AF, de-la-Riva GA, Lopez-Revilla R. Characterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice. Braz J Med Biol Res. Feb 2000;33(2):147-155

Ebolapox
05-12-2011, 10:43 AM
As a scientific rebuttal:

NOTE: GM lobbyists are claiming it doesn't matter if the Bt toxin is turning up in people's blood because the Bt toxin is natural, known to be harmless to humans, and has been safely used for decades in agriculture in the form of natural insecticidal sprays, including in organic farming. In addition, they say, Bt crops have been tested and approved as safe.

But the Bt toxin produced in GM crops is not the same as the natural Bt toxin. The process of genetic engineering changes it. And testing is not actually performed on the Bt toxin extracted from GM plants, which would be the scientific way, as it is claimed that it is too expensive to isolate.

GM Bt toxins are engineered into plants with promoters designed to keep the Bt toxin protein expressing in every cell of the plant. The Bt is ingested by animals and people who consume crop plants like Bt maize. The natural Bt used in agricultural sprays, by contrast, degrades rapidly in daylight and does not end up being eaten by people, so it is unlikely to ever end up in consumers' bodies.

This is fortunate because even natural Bt can cause harm when ingested. Studies show that it has ill effects on laboratory animals, producing a potent immune response and enhancing the immune response to other substances.

Vázquez RI, Moreno-Fierros L, Neri-Bazan L, De La Riva GA, Lopez-Revilla R. Bacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant. Scand J Immunol. Jun 1999;49(6):578-584.

Vázquez-Padrón RI, Moreno-Fierros L, Neri-Bazan L, de la Riva GA, Lopez-Revilla R. Intragastric and intraperitoneal administration of Cry1Ac protoxin from Bacillus thuringiensis induces systemic and mucosal antibody responses in mice. Life Sci. 1999;64(21):1897-1912.

Vázquez-Padrón RI, Moreno-Fierros L, Neri-Bazan L, Martinez-Gil AF, de-la-Riva GA, Lopez-Revilla R. Characterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice. Braz J Med Biol Res. Feb 2000;33(2):147-155

thanks for the response, this is what stirs actual scintillating scientific inquiry. are there concerns over genetic modification? absolutely. almost ANYTHING a person takes in has a potential to be an immunogen and elicit an immune response. I wasn't aware that they weren't testing on the GM toxin; however, if one knows anything about genetic engineering, they clone in the exact genetic sequence for the toxin... the only modification is made to add a promotor that is constitutively active (so it has an effect). the toxin, however, should be (if it's done properly) exactly the same as that found in nature. if it isn't, then you've got some shoddy labwork and issues naturally ensue from that.

my only real beef is with those who, regardless of knowing the facts or ANY background information, freak out because it's different and they don't understand it. ignorance is not bliss, IMO (and there are a ton of people running around who are very ignorant when it comes to anything sciency)

Amnorix
05-12-2011, 11:00 AM
you'd be shocked at the amount of people who (even if they've had a high school biology class) know absolutely NOTHING about science and consider it magic (they won't call it that, but there's a certain mysticism that the uneducated hold for biology/science).

it really is a shame, because issues like this are amplified when you have a bunch of herp-a-derps running around freaking out and they, in turn, drag other people into their web of freakout.

But, but, but, but TOXINS IN OUR BLOOD -- WE'RE GONNA DIE!!!!

:deevee::deevee::deevee:










:P

HonestChieffan
05-12-2011, 12:38 PM
seems that they found a protein.....no claim that it is toxic....and no data would support it....but the headline is the story.

Iowanian
05-12-2011, 01:15 PM
Cool.


maybe by kids will be able to bench 500lbs.

Chiefnj2
05-12-2011, 01:32 PM
Genetically Modified Foods

According to the World Health Organization, Genetically Modified Organisms(GMOs) are "organisms in which the genetic material (DNA) has been altered in such a way that does not occur naturally."1 This technology is also referred to as "genetic engineering", "biotechnology" or "recombinant DNA technology" and consists of randomly inserting genetic fragments of DNA from one organism to another, usually from a different species. For example, an artificial combination of genes that includes a gene to produce the pesticide Cry1Ab protein (commonly known as Bt toxin), originally found in Bacillus thuringiensis, is inserted in to the DNA of corn randomly. Both the location of the transferred gene sequence in the corn DNA and the consequences of the insertion differ with each insertion. The plant cells that have taken up the inserted gene are then grown in a lab using tissue culture and/or nutrient medium that allows them to develop into plants that are used to grow GM food crops.2

Natural breeding processes have been safely utilized for the past several thousand years. In contrast, "GE crop technology abrogates natural reproductive processes, selection occurs at the single cell level, the procedure is highly mutagenic and routinely breeches genera barriers, and the technique has only been used commercially for 10 years."3

Despite these differences, safety assessment of GM foods has been based on the idea of "substantial equivalence" such that "if a new food is found to be substantially equivalent in composition and nutritional characteristics to an existing food, it can be regarded as safe as the conventional food."4 However, several animal studies indicate serious health risks associated with GM food consumption including infertility, immune dysregulation, accelerated aging, dysregulation of genes associated with cholesterol synthesis, insulin regulation, cell signaling, and protein formation, and changes in the liver, kidney, spleen and gastrointestinal system.

There is more than a casual association between GM foods and adverse health effects. There is causation as defined by Hill's Criteria in the areas of strength of association, consistency, specificity, biological gradient, and biological plausibility.5 The strength of association and consistency between GM foods and disease is confirmed in several animal studies.2,6,7,8,9,10,11

Specificity of the association of GM foods and specific disease processes is also supported. Multiple animal studies show significant immune dysregulation, including upregulation of cytokines associated with asthma, allergy, and inflammation. 6,11 Animal studies also show altered structure and function of the liver, including altered lipid and carbohydrate metabolism as well as cellular changes that could lead to accelerated aging and possibly lead to the accumulation of reactive oxygen species (ROS). 7,8,10 Changes in the kidney, pancreas and spleen have also been documented. 6,8,10 A recent 2008 study links GM corn with infertility, showing a significant decrease in offspring over time and significantly lower litter weight in mice fed GM corn.8 This study also found that over 400 genes were found to be expressed differently in the mice fed GM corn. These are genes known to control protein synthesis and modification, cell signaling, cholesterol synthesis, and insulin regulation. Studies also show intestinal damage in animals fed GM foods, including proliferative cell growth9 and disruption of the intestinal immune system.6

Regarding biological gradient, one study, done by Kroghsbo, et al., has shown that rats fed transgenic Bt rice trended to a dose related response for Bt specific IgA. 11

Also, because of the mounting data, it is biologically plausible for Genetically Modified Foods to cause adverse health effects in humans.

In spite of this risk, the biotechnology industry claims that GM foods can feed the world through production of higher crop yields. However, a recent report by the Union of Concerned Scientists reviewed 12 academic studies and indicates otherwise: "The several thousand field trials over the last 20 years for genes aimed at increasing operational or intrinsic yield (of crops) indicate a significant undertaking. Yet none of these field trials have resulted in increased yield in commercialized major food/feed crops, with the exception of Bt corn."12 However, it was further stated that this increase is largely due to traditional breeding improvements.

Therefore, because GM foods pose a serious health risk in the areas of toxicology, allergy and immune function, reproductive health, and metabolic, physiologic and genetic health and are without benefit, the AAEM believes that it is imperative to adopt the precautionary principle, which is one of the main regulatory tools of the European Union environmental and health policy and serves as a foundation for several international agreements.13 The most commonly used definition is from the 1992 Rio Declaration that states: "In order to protect the environment, the precautionary approach shall be widely applied by States according to their capabilities. Where there are threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost-effective measures to prevent environmental degradation."13

Another often used definition originated from an environmental meeting in the United States in 1998 stating: "When an activity raises threats to the environment or human health, precautionary measures should be taken, even if some cause and effect relationships are not fully established scientifically. In this context, the proponent of an activity, rather than the public, should bear the burden of proof (of the safety of the activity)."13

With the precautionary principle in mind, because GM foods have not been properly tested for human consumption, and because there is ample evidence of probable harm, the AAEM asks:


Physicians to educate their patients, the medical community, and the public to avoid GM foods when possible and provide educational materials concerning GM foods and health risks.

Physicians to consider the possible role of GM foods in the disease processes of the patients they treat and to document any changes in patient health when changing from GM food to non-GM food.

Our members, the medical community, and the independent scientific community to gather case studies potentially related to GM food consumption and health effects, begin epidemiological research to investigate the role of GM foods on human health, and conduct safe methods of determining the effect of GM foods on human health.

For a moratorium on GM food, implementation of immediate long term independent safety testing, and labeling of GM foods, which is necessary for the health and safety of consumers.

(This statement was reviewed and approved by the Executive Committee of the American Academy of Environmental Medicine on May 8, 2009.)

Submitted by Amy Dean, D.O. and Jennifer Armstrong, M.D.




Bibliography: Genetically Modified Foods Position Paper AAEM

World Health Organization. (Internet).(2002). Foods derived from modern technology: 20 questions on genetically modified foods. Available from: http://www.who.int/foodsafety/publications/biotech/20questions/en/index.html

Smith, JM. Genetic Roulette. Fairfield: Yes Books.2007. p.10

Freese W, Schubert D. Safety testing and regulation of genetically engineered foods. Biotechnology and Genetic Engineering Reviews. Nov 2004. 21.

Society of Toxicology. The safety of genetically modified foods produced through biotechnology. Toxicol. Sci. 2003; 71:2-8.

Hill, AB. The environment and disease: association or causation? Proceeding of the Royal Society of Medicine 1965; 58:295-300.

Finamore A, Roselli M, Britti S, et al. Intestinal and peripheral immune response to MON 810 maize ingestion in weaning and old mice. J Agric. Food Chem. 2008; 56(23):11533-11539.

Malatesta M, Boraldi F, Annovi G, et al. A long-term study on female mice fed on a genetically modified soybean:effects on liver ageing. Histochem Cell Biol. 2008; 130:967-977.

Velimirov A, Binter C, Zentek J. Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice. Report-Federal Ministry of Health, Family and Youth. 2008.

Ewen S, Pustzai A. Effects of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine.Lancet. 354:1353-1354.

Kilic A, Aday M. A three generational study with genetically modified Bt corn in rats: biochemical and histopathological investigation. Food Chem. Toxicol. 2008; 46(3):1164-1170.

Kroghsbo S, Madsen C, Poulsen M, et al. Immunotoxicological studies of genetically modified rice expression PHA-E lectin or Bt toxin in Wistar rats. Toxicology. 2008; 245:24-34.

Gurain-Sherman,D. 2009. Failure to yield: evaluating the performance of genetically engineered crops. Cambridge (MA): Union of Concerned Scientists.

Lofstedt R. The precautionary principle: risk, regulation and politics. Merton College, Oxford. 2002.

KILLER_CLOWN
05-12-2011, 03:31 PM
I posted this article for those that have eyes to see and ears to hear, by all means accept all "Scientific" data at face value. The individual is responsible for his/her self, if you want to indulge in contaminated food you should have the right, the rest of us want to know what goes into our temple.

Inspector
05-13-2011, 10:57 AM
GN should stick to making cars and stay out of the farming business. No wonder they screwed it up. You simply cannot blend corn and a new Tahoe together.

Dumbasses!

boogblaster
05-13-2011, 11:08 AM
they spray the ground here .. it kills the undergrowth .. then they plant right over it .. hummm .. guess nuttin' happens in that toxic ground to hurt ya ... wonder why our cancer rate is higher that most countries .. prolly sumpin to do with our over-population .....

FishingRod
05-13-2011, 11:57 AM
CATDOG