If you're absolutely positive it isn't the tires then yea, I suppose it could be the drive shaft. But those things don't just go out of balance, or throw a weight. If you can, put the rear end on jack stands to get the tires off the ground and put the transmission in neutral then crawl under it and spin the drive shaft slowly by hand. What you're looking for is a dent anywhere along it indicating it's been hit by something and bent. It doesn't take much, the tubes used to build drive shafts have surprising thin walls.
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Like "Cool Hand" Luke I'm busting rocks.
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