Typically the use of an external mouse won't deactivate the touchpad, but your setup may be different. There may also be a button, often a horizontal bar, near the touchpad that will turn it on and off.
Worse comes to worse, you could always uninstall and reinstall the driver for your touchpad from the device manager (system control panel, hardware tab). Just remove it and then reinstall it.
If none of this helps, let me know what type of laptop you have and I'll see what I can find.
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