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Eisenbud, was the principle investigator of the Lorain Incident and through his work, it was decide that there should be some type of limits for beryllium exposure. What he decided was that there was a need for two separate limits based on the premise that the acute disease was a direct dose-response, and the chronic disease which appeared to be a selective response of the immune system. Essentially what was derived from his findings was that to prevent being afflicted with the acute disease, a single exposure ceiling level was needed and to keep from getting the chronic beryllium disease, a long term average exposure was need for those that constantly worked with beryllium.
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