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The Chargers have a top 5 QB in the league and are facing a defense that can't force turnovers or put pressure on the QB.
The Chiefs can hope for an implosion of some sort, which is somewhat likely to happen given it's the early season Chargers, but that's about the only way they can win the game. While the Chargers defense isn't special at all, Matt Cassel is hardly the answer to putting this disjointed offense together and scoring a buttload of points (which is what it's going to take to outscore the Chargers).
That's why the Chargers are favored to win.
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