Wilfred was a miss early on with me, but I like it now.
The pot smoking stuff doesn't work so well for me, I don't 'get' it (can't relate), but the sexual humor...
I actually haven't watched Louie since the episode with the old lady who died. That one just didn't work at all for me. But I've got the others dvr'd and might watch them now, now that I'm thinking about it.