Can only field 2 RB's. Must choose between...
Adrian Peterson (Wash - 9th against the run)
Ryan Mathews (Den - 17th against the run)
Rashard Mendenhall (Ten - 23rd against the run)
Considering Mendy is still fresh off the injury I'm thinking the top 2 but there's something about watching your guy on a prime time game plus the tasty matchup against a useless Tenn D. Tough call.