Just bought a 2009 Highlander Limited Hybrid a few months back for the wife and she absolutely loves it. Anything Hybrid related has factory warranty until 100k. This is my first hybrid and I'm a fan. It's nice to have a SUV in the house that gets 27 MPG, considering mine gets me about 11 MPG. I've owned many Toyota's and have never had an issue with anything, my Porsche on the other hand...
From my research, the only other Hybrid SUV in the same price range that gets better MPG is the new Escape with around 32 MPG. I recommend the Highlander, and even though you may see a gazillion of them around town, most of them are not hybrids.