My dad grabbed one of these this weekend:
S&W Governor. 6-round cylinder that fires .410 shells, .45 Colts and .45 ACP rounds. It's pretty much built for killing stuff. Looks like a blast to shoot.
I keep inching slowly towards picking up my Beretta 96:
That thing just feels so nice in your hand. I could live without the dual stage trigger, but everything else about the gun is just perfect for me. Oh, and it's still the best looking handgun ever made, IMO.