Here's a post I made in another thread.
One thing that needs to be cleared up that #1 picks are more valuable under the new CBA than under the old one. You don't want to waste them.
The reasoning that says "well, we don't have to spend as much money on this #1 pick, so lets just pick a QB and roll the dice." That is bogus. The #1 pick is worth more in compensation through trades with the new CBA. You forfeit more potential players via trade now than ever before if you are not willing to trade down.
Look at the following non QB trades:
http://espn.go.com/nfl/draft2012/sto.../trade-tracker
Cleveland Browns: Acquire pick No. 3 in 2012 Trent Richardson
Minnesota Vikings: Acquire picks No. 4, No. 118, No. 139 and No. 211 Matt Kalil
Jacksonville Jaguars: Acquire pick No. 5 in 2012 Justin Blackmon
Tampa Bay Buccaneers: Acquire picks No. 7 and No. 101 Mark Barron
Dallas Cowboys: Acquire pick No. 6 in 2012 Morris Claiborne
St. Louis Rams: Acquire picks No. 14 and No. 45 Michael Brockers
Philadelphia Eagles: Acquire pick No. 12 in 2012 Fletcher Cox
Seattle Seahawks: Acquire picks No. 15, No. 114 and No. 172 Bruce Irvin
New England Patriots: Acquire pick No. 21 in 2012 Chandler Jones
Cincinnati Bengals: Acquire picks No. 27 and No. 93 Kevin Zeitler
NewEngland Patriots: Acquire pick No. 25 in 2012 Donta Hightower
Denver Broncos: Acquire picks No. 31 and No. 126 Doug Martin
Minnesota Vikings: Acquire pick No. 29 in 2012 Harrison Smith
Baltimore Ravens: Acquire picks No. 35 and No. 98 Courtney Upshaw
Tampa Bay Buccaneers: Acquire picks No. 31 and No. 126 Doug Martin
Denver Broncos: Acquire picks No. 36 and No. 101 Derek Wolfe