Thread: Science Science is Cool....
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Old 02-03-2013, 04:02 PM   #553
Cephalic Trauma Cephalic Trauma is offline
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Quote:
Originally Posted by Fish View Post
You're simply arguing the semantics of my own description. And you're not even doing it very well. You haven't even bothered to attempt an intelligent rebuttal. But whatever. Science been overcoming what people like you call impossible, for quite a while now, and it will continue to do so.

And by the way, the video you casually dismissed because of its source was done by someone with a Masters in neuroscience who has published research in neuronal cell culture techniques, and computational neurophysiology. She makes a living teaching science.

Why don't you try and contribute something besides snarky doucheness?
No, I'm arguing the accuracy of your description. Science has been overcoming people like me? What? I'm a medical student.

A brief history in genetic therapy from a lecture series presented by a well-published MD/PhD:

1960ís
Researchers foresaw manipulations of chromosomes and genes for "desired" genes
Must be cautious to control genes until we completely understand effects
1970ís
Began experimentation on humans
Tried treating people with arginemia virus that would cause reduction of arginine in blood
Aftermath of ethical issues caused pessimism over gene therapy
1980ís
Tried to treat patients with beta-thalessemia without IRB approval
Lead to resignation and penalties to UCLA
1990ís
Infused gene into bone marrow cells
Could put cells into subjects, but not at a high enough level to be effective
Another experiment killed a patient because of serious problems with experimental setup
2000ís
Successful treatments of melanoma, color blindness in squirrel monkeys, partial vision to blind, CLL (leukemia)


Yes, we have come a long way. But we've tried manipulating genes as a treatment for a while now, with many obstacles. These are the obstacles I have been referring to.

Barriers to Gene Therapy
1. Therapy must be applied frequently due to poor half-life
2. Viral vectors used to apply treatment can cause immune response
3. Unintended cosequences, such as inflammatory responses
4. Target other tissues that arenít desired
5. Poor efficiency- even if they target the appropriate tissue, doesnít always work well


There's your contribution.

Sincerely,
Snarky Douche
Posts: 4,095
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