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It's really hard to know without seeing it and the varmints you are talking about.
The bugs are probably OK, but if you're worried about it, get some insecticide.
As for the weeds, I'd recommend you terminate them before you till. You need a non-selective herbicide. Glyphosate with some 2-4D works the best in most situations. I don't know what you can get for yourself, but beware of Roundup branded products. They have added a lot of residuals and other crap to just straight roundup. Don't buy anything that says extended control or anything like that. If you can get to a store with somebody that knows something, just ask for straight roundup. Spray it. Wait 2 weeks for the weeds to die. Till.
Find shit. Manure is your best friend.
Fertilize. You're going to need nitrogen, phosphorus, and potassium most likely. Most greenhouses will be able to fix you up. Just make sure you read the directions. Sometimes there is timing issues with picking, flowering, and the like, just read the directions.
Mulch. A lot. It will cut down your water usage through evaporation and keep the weeds out.
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