Amex is the best for cash back at the end of the year, but also carry the highest annual fees. The southwest one is the best of the flight ones as far as I can tell, you get more flyer miles with the airline specific ones (obviously). The chase cards have the most up front bonus points if you spend 3-5k in the first three months depending on which one you get.
I use the Southwest one for business and the chase sapphire for personal spending/bills. All of them have pluses and minuses, just a matter of getting one that you want.
One thing I do love about the chase card is that when you call their customer service line a person answers, so you don't have to deal with all the talking to a computer bullshit.
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