In my experience (one alcoholic sister-in-law and one depressed close friend), there is only so much you can do to help someone. I would say that keeping your brother away from alcohol and drugs as much as possible is a good start. Literally knock the beer out of his hands if you see him with it. Try to get him to counseling. Try to get everyone who knows him aware of the problem and try to get them to offer support (phone calls, visits, counsel, etc.).
Sadly, you also need to prepare yourself as best as you can for the worst because, ultimately, your brother's depression and addiction are beyond your control. I wish I could be more encouraging but people have to help themselves.
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