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Old 10-25-2015, 04:12 PM   #1
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Quote:
Originally Posted by Cunning Linguist View Post
https://www.sciencebasedmedicine.org...t-cure-cancer/

Just an FYI. The studies just don't support the idea that recreational use of cannabis can shrink tumors. I specifically posted the glioma section of this well-written article because I'm assuming "GBM" is glioblastoma multiforme, which is a malignant growth of glial cells.

In essence, most studies have been done in animal models, and have shown anti-tumor effects at ridiculously high doses (~1000 joints).

I just want to make you aware of what is known and make an educated decision.
I also think there is a CBD component is that is missing from the studies you cite
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Old 10-25-2015, 04:18 PM   #2
Don Corlemahomes Don Corlemahomes is offline
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Originally Posted by DenverChief View Post
I also think there is a CBD component is that is missing from the studies you cite
Any information or studies on the component you are referring to?
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Old 10-25-2015, 04:30 PM   #3
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Originally Posted by Cunning Linguist View Post
Any information or studies on the component you are referring to?
Not that I have personally researched. The CBD compound has been mentioned in several documentaries for it's medical value for seizures - and I'm pretty sure for tumor reduction. I have a friend of the family that used CBD oil for a tumor in the colon and combined with chemo the Dr's were surprised by the amount of reduction.

EDIT: I should mention it was ingested orally
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Old 10-25-2015, 04:38 PM   #4
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http://www.ncbi.nlm.nih.gov/pubmed/20053780

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Recently, cannabinoids (CBs) have been shown to possess antitumor properties. Because the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the present study to evaluate the in vitro antiproliferative ability of cannabidiol (CBD), a nonpsychoactive cannabinoid compound, on U87 and U373 human glioma cell lines. The addition of CBD to the culture medium led to a dramatic drop of mitochondrial oxidative metabolism [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide test] and viability in glioma cells, in a concentration-dependent manner that was already evident 24 h after CBD exposure, with an apparent IC(50) of 25 microM. The antiproliferative effect of CBD was partially prevented by the CB2 receptor antagonist N-[(1S)-endo-1,3,3-trimethylbicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528; SR2) and alpha-tocopherol. By contrast, the CB1 cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboximide hydrochloride (SR141716; SR1), capsazepine (vanilloid receptor antagonist), the inhibitors of ceramide generation, or pertussis toxin did not counteract CBD effects. We also show, for the first time, that the antiproliferative effect of CBD was correlated to induction of apoptosis, as determined by cytofluorimetric analysis and single-strand DNA staining, which was not reverted by cannabinoid antagonists. Finally, CBD, administered s.c. to nude mice at the dose of 0.5 mg/mouse, significantly inhibited the growth of subcutaneously implanted U87 human glioma cells. In conclusion, the nonpsychoactive CBD was able to produce a significant antitumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent.
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Old 10-25-2015, 04:39 PM   #5
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Originally Posted by DenverChief View Post
Not that I have personally researched. The CBD compound has been mentioned in several documentaries for it's medical value for seizures - and I'm pretty sure for tumor reduction. I have a friend of the family that used CBD oil for a tumor in the colon and combined with chemo the Dr's were surprised by the amount of reduction.
I'm just going to tap out here.

We could talk about anecdotal evidence vs. actual trials, colon and GBM being completely different tumors made up of completely different tissue and governed by completely different mediators of tumor cell growth, dosages, delivery to the colon (delivered directly to the colon by ingestion) vs. the brain (must be taken up into the bloodstream, metabolized by the liver, traverse the Blood-brain barrier, and delivered to the site of the tumor in high enough concentrations) etc etc, but I don't think we will agree.
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Old 10-26-2015, 04:49 AM   #6
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I meet people everyday that are sent by their oncologists. We have them ingesting 1000mgs of THC and 250 of CBD. Not only are visible growths shrinking, we have a gross amount of anecdotal success stories. To the point of national exposure on tv.

It should be next to the aspirin in stores. Until then I guess my boss will just get richer. And if you want to see the funniest most awful riot ever, just try and criminalize weed now. Old people will freak the **** out.
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Old 10-26-2015, 12:48 PM   #7
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Quote:
Originally Posted by Cunning Linguist View Post
https://www.sciencebasedmedicine.org...t-cure-cancer/

Just an FYI. The studies just don't support the idea that recreational use of cannabis can shrink tumors. I specifically posted the glioma section of this well-written article because I'm assuming "GBM" is glioblastoma multiforme, which is a malignant growth of glial cells.

In essence, most studies have been done in animal models, and have shown anti-tumor effects at ridiculously high doses (~1000 joints).

I just want to make you aware of what is known and make an educated decision.
1,000 joints?? where can i sign up to be a research subject?
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Old 10-26-2015, 01:32 PM   #8
Don Corlemahomes Don Corlemahomes is offline
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Originally Posted by go bowe View Post
1,000 joints?? where can i sign up to be a research subject?


I support legalization, medicinal marijuana, etc. I hope my science rhetoric in this thread didn't make me come off like an old-school square.
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Old 10-25-2015, 04:09 PM   #9
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So I'm assuming you would want a CBD oil (medicinal/anti seizure) that doesn't get you real high.....or do you want the effects?

I can hook you up with a cooking oil that you can use and dose yourself as you like. That will last longer than the other oil that comes in a syringe. That is just one & done, generally.....
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Old 10-25-2015, 04:44 PM   #10
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When my brother was up at Mayo in 2012/2013 they asked his oncologist about CBD, weed etc as treatment for his stage 4 GBM.

The doc said it was showing to kill the tumor, but the only way it'd been tested was direct injection into the tumor.

Which led to the two problems with that. One, not every tumor can be reached, and two, nobody was making the stuff in a way a doctor would ever approve as clean enough to inject directly into someone's brain.

Weed and the polio virus currently look like the best hopes, which is great!
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Old 10-25-2015, 04:46 PM   #11
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Originally Posted by Bewbies View Post
When my brother was up at Mayo in 2012/2013 they asked his oncologist about CBD, weed etc as treatment for his stage 4 GBM.

The doc said it was showing to kill the tumor, but the only way it'd been tested was direct injection into the tumor.

Which led to the two problems with that. One, not every tumor can be reached, and two, nobody was making the stuff in a way a doctor would ever approve as clean enough to inject directly into someone's brain.

Weed and the polio virus currently look like the best hopes, which is great!
Right. That is in the article as well. They resected the tumor (took it out surgically), then administered cannabinoid oil directly into the residual tumor, which is much different than just ingesting it.
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Old 10-25-2015, 04:56 PM   #12
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I'm sorry if I personally attacked you, Denver. That was not my intention. I got a little worked up.
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Old 10-25-2015, 05:04 PM   #13
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Originally Posted by Cunning Linguist View Post
I'm sorry if I personally attacked you, Denver. That was not my intention. I got a little worked up.

No harm, no foul - I just wanted you to understand where I was coming from
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Old 10-25-2015, 05:12 PM   #14
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No harm, no foul - I just wanted you to understand where I was coming from
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Old 10-26-2015, 12:30 PM   #15
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Purely hypothetical conversation I had with a friend last weekend. If someone stumbled on some totally natural, "magic" cure for all types of cancer, something like rubbing an acorn on your elbow, would the behemoth cancer industry ever let us know about it? Think of all the billions of dollars that industry brings in. Doctors/surgeons salaries, research grants/researcher salaries, chemo, radiation, etc. I'm skeptical that--if some easy, natural cure that couldn't be patented by Big Pharma were found--we would ever hear about it. I don't mean to imply that everyone involved in cancer research is corrupt by any means, but it seems naive to believe that the whole industry would just fold up their tents and find new careers. There are billions and billions of dollars involved in maintaining status quo.
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