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12-27-2011, 11:40 PM
Pheniramine (Avil) is an antihistamine (http://en.wikipedia.org/wiki/Antihistamine) with anticholinergic (http://en.wikipedia.org/wiki/Anticholinergic) properties used to treat allergic (http://en.wikipedia.org/wiki/Allergy) conditions such as hay fever (http://en.wikipedia.org/wiki/Hay_fever) or urticaria (http://en.wikipedia.org/wiki/Urticaria).
It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine (http://en.wikipedia.org/wiki/Diphenhydramine).
Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself.
As an example, Neo Citran (http://en.wikipedia.org/wiki/Neo_Citran) contains pheniramine.
Derivatives of pheniramine include chlorpheniramine (http://en.wikipedia.org/wiki/Chlorpheniramine), dexchlorpheniramine (http://en.wikipedia.org/wiki/Dexchlorpheniramine), dexbrompheniramine (http://en.wikipedia.org/wiki/Dexbrompheniramine), deschlorpheniramine (http://en.wikipedia.org/w/index.php?title=Deschlorpheniramine&action=edit&redlink=1), triprolidine (http://en.wikipedia.org/wiki/Triprolidine), and brompheniramine (http://en.wikipedia.org/wiki/Brompheniramine). Two other halogenated derivatives, iodopheniramine (http://en.wikipedia.org/w/index.php?title=Iodopheniramine&action=edit&redlink=1) and fluorpheniramine (http://en.wikipedia.org/w/index.php?title=Fluorpheniramine&action=edit&redlink=1), are currently in use for research on combination therapies for malaria and some cancers. The halogenation (http://en.wikipedia.org/wiki/Halogenation) of pheniramine increases its potency by 20-fold.
Avil may cause drowsiness, bradycardia (http://en.wikipedia.org/wiki/Bradycardia) and over-dosage may lead to sleep disorders. Overdose may lead to seizures (http://en.wikipedia.org/wiki/Seizures), especially in combination with alcohol. People combining with cortisol (http://en.wikipedia.org/wiki/Cortisol) in the long term should avoid Avil as it may cause lowered levels of adrenaline which may lead to loss of consciousness.
Sources:
Leaflet on Avil (http://www.racgp.org.au/cmi/swcavilt.pdf) by The Royal Australian College of General Practitioners (http://en.wikipedia.org/wiki/Royal_Australian_College_of_General_Practitioners)
http://en.wikipedia.org/wiki/Pheniramine
If you want to look at gloaba pharmacological data you can check out this link: https://www.google.com/search?source=ig&hl=en&rlz=&q=global+pharmacological+data&oq=global+pharmacological+data&aq=f&aqi=&aql=&gs_sm=e&gs_upl=654l11317l0l12733l29l26l0l5l3l1l248l3692l0.12.8l21l0
It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine (http://en.wikipedia.org/wiki/Diphenhydramine).
Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself.
As an example, Neo Citran (http://en.wikipedia.org/wiki/Neo_Citran) contains pheniramine.
Derivatives of pheniramine include chlorpheniramine (http://en.wikipedia.org/wiki/Chlorpheniramine), dexchlorpheniramine (http://en.wikipedia.org/wiki/Dexchlorpheniramine), dexbrompheniramine (http://en.wikipedia.org/wiki/Dexbrompheniramine), deschlorpheniramine (http://en.wikipedia.org/w/index.php?title=Deschlorpheniramine&action=edit&redlink=1), triprolidine (http://en.wikipedia.org/wiki/Triprolidine), and brompheniramine (http://en.wikipedia.org/wiki/Brompheniramine). Two other halogenated derivatives, iodopheniramine (http://en.wikipedia.org/w/index.php?title=Iodopheniramine&action=edit&redlink=1) and fluorpheniramine (http://en.wikipedia.org/w/index.php?title=Fluorpheniramine&action=edit&redlink=1), are currently in use for research on combination therapies for malaria and some cancers. The halogenation (http://en.wikipedia.org/wiki/Halogenation) of pheniramine increases its potency by 20-fold.
Avil may cause drowsiness, bradycardia (http://en.wikipedia.org/wiki/Bradycardia) and over-dosage may lead to sleep disorders. Overdose may lead to seizures (http://en.wikipedia.org/wiki/Seizures), especially in combination with alcohol. People combining with cortisol (http://en.wikipedia.org/wiki/Cortisol) in the long term should avoid Avil as it may cause lowered levels of adrenaline which may lead to loss of consciousness.
Sources:
Leaflet on Avil (http://www.racgp.org.au/cmi/swcavilt.pdf) by The Royal Australian College of General Practitioners (http://en.wikipedia.org/wiki/Royal_Australian_College_of_General_Practitioners)
http://en.wikipedia.org/wiki/Pheniramine
If you want to look at gloaba pharmacological data you can check out this link: https://www.google.com/search?source=ig&hl=en&rlz=&q=global+pharmacological+data&oq=global+pharmacological+data&aq=f&aqi=&aql=&gs_sm=e&gs_upl=654l11317l0l12733l29l26l0l5l3l1l248l3692l0.12.8l21l0