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Originally Posted by SupDock
What are your thoughts on plaquenil and azithromycin combined?
In the hospital I am not too concerned because you can just watch their QT interval.
6 or 7 days isn't very long, but just wanted your opinion on risk in the outpatient setting. Especially if we are targeting therapy at our higher risk, elderly Covid patients.
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I'd be concerned starting on anyone on that combo w/ a QT interval greater than 475. Over 500 would be an absolute CI d/t Torsades risk.
I don't know if we should be dispensing outpatient Rx for it at all. If most carriers are asymptomatic, I think you're only encouraging resistance with limited clinical benefit while also depriving people w/ RA and Lupus of a necessary medication.
I'm a bit curious about the use of azithromycin at all given increasing Strep pneumo resistance (maybe try Doxy instead). The trial said it was used to prevent bacterial superinfection, but the real benefit might be from its anti-inflammatory properties.
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"When the Know-Nothings get control, it will read 'all men are created equal, except negroes, and foreigners, and Catholics.' When it comes to this I should prefer emigrating to some country where they make no pretense of loving liberty – to Russia, for instance, where despotism can be taken pure, and without the base alloy of hypocrisy.”--Abraham Lincoln
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