Quote:
Originally Posted by petegz28
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Just read an article reviewing the dexamethasone report
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Clinical Take Home Point:*The findings of this well done randomized controlled trial indicate that in patients with COVID-19 pneumonia, that dexamethasone improves 28d mortality compared to placebo in patients requiring IMV (NNT = 8.5) and those patients requiring oxygen therapy (NNT = 29).* There was no benefit to patients not requiring oxygenation support and even a signal for harm.* It is important to remember this is a preprint, preliminary report, which is better than a press release. At this time, in patients requiring any oxygen therapy, HFNC, NIV, IMV, or ECMO I would recommend dexamethasone until further evidence disproves this benefit.
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So clinical improvement in mortality for patients on oxygent
Number needed to treat is 29 patients on oxygen
Number needed to treat is 8.5 patients on a ventilator.
Cool study.
I was just commenting on the fact that steroids are very commonly used in the ICU for respiratory conditions.