Quote:
Originally Posted by TLO
I have that study printed off already to show my doctor. 
Well, one of the numerous studies I found that say that exact same thing. |
Here's a good one too
https://www.google.com/url?sa=t&sour...J-clz4YxDQQ51S
False positive rates for benzodiazepine immunoassays are relatively low (<5 percent).
However, most benzodiazepine immunoassays used for screening are susceptible to false
negative results. The false-negative rate for benzodiazepines in an immunoassay screen is
approximately 25-30 percent, and is particularly problematic for clonazepam. One reason
for false-negative clonazepam results is that the drug appears in the urine almost entirely as
7-aminoclonazepam, a metabolite that is not detected by many commercial immunoassay
screens. A similar challenge exists for some other extensively metabolized benzodiazepines.
Concerns about false-negative results in confirmation/quantitation tests for
benzodiazepines also exist due to variation among laboratories in the cutoff concentrations
(sensitivity), the actual analytes detected, and the sample preparation methods. Regarding
sample preparation, some laboratory methods includes a sample pretreatment reaction prior
to analysis that liberates glucuronide metabolites (e.g., hydrolysis). Hydrolysis pretreatment
will improve detection of most benzodiazepines. Inclusion of multiple benzodiazepine
metabolites will also improve detection of benzodiazepines in urine confirmation/
quantitation tests.