Quote:
Originally Posted by 'Hamas' Jenkins
Makes sense. Low dose ritonavir is given with several other protease inhibitors because it inhibits CYP 3A4, which is the most common cytochrome P450 enzyme for drug metabolism in humans. It's not really given because it's a protease inhibitor, but because of its enzyme inhibition.
By slowing the metabolism of the drug, you are able to increase the effective dose because it isn't cleared from the body as quickly.
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This is exactly what I was thinking......