I blocked after the .com, adding an asterick after the slash. It will block all of them.
The downside of blocking too much would be if you blocked an entire domain that actually served a purpose, however most major sites farm out their ads to other domains such as "adclick" or "doubleclick"..etc. Rarely do ads belong to the root of the domain. Also, using the wildcard helps because it will block all images, flash videos, and "iframes" from that source.
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