I don't think you can go wrong with either of your options, but I'd keep 2 RBs.
Manning is a step above other QBs, but the disparity between him and a QB like Delhomme, who can be had later in the draft, is much less than LJ and someone you'd find in the corresponding round.
Just as an example, in a 12 team league, Delhomme's ADP is the bottom of the 6th round, where the RBs being picked are players like McAllister, Maroney, Brown, Gore, etc.
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