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Honestly, I think a continuation of the global financial system unraveling is probably the most likely source of cataclysm, even though the nerd in me wants to think that a killer virus (affecting humans, plants, animals, whatever) could wipe out enough things to seriously hurt the US.
That said, I don't think any of these things are likely. So many things have to fall into place for these situations to gain serious traction and spread enough to be a cataclysmic event that I doubt seriously they will happen.
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