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I think your best option is to put as much sheer speed on the field as possible.
SF will key on Charles. So you set him over to one side, and McCluster the other. Put your tight ends out on the edges (Moeaki and O'Connell), and put your WRs in close to the OL (Bowe and Chambers).
Do whatever you can to break the SF defense from crunching down on the box by giving them different looks. Not gadget plays. Different looks.
And it's Patrick Willis. Know your elite football players or get ready to meet the AIDS tree.
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