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Originally Posted by POND_OF_RED
I tried to get his idea of when he would be comfortable with the research for a vaccine to trust the NNT NNH and Fatality rate %’s enough to get the vaccine himself. He answered all the questions like a politician running for office using his medical terminology to go right over most peoples heads. I’m not oblivious to what he’s saying. The most we could ever get out of him is that this fall would be too early. You would think a pharmacist would be happy to share there input on a timeline needed for a safe vaccine. Most pharmacists I work with have told me they wouldn’t want to see one rushed before next fall so I was wondering if he felt the same way. He can’t just answer in simple terms how he feels about the timeline?
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This is just horseshit.
When you asked me about getting the vaccine and what I would do:
Quote:
Originally Posted by 'Hamas' Jenkins
Post-marketing surveillance will bring forth rare issues you won't see in even large RCT. However, it's pretty simple to me: number needed to treat vs number needed to harm vs the fatality rate of the disease.
If the NNT is lower than NNH and the NNH translates to a lower percentage than the fatality rate for my cohort, I'd get the vaccine.
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When you asked about how soon it would be available:
Quote:
Originally Posted by 'Hamas' Jenkins
I have no better idea than you do. I don't think fall is reasonable just from a scale perspective. Oxford isn't even in human trials yet.
Correction: Oxford is now in Phase I trials.
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When you asked if I was worried.
Quote:
Originally Posted by 'Hamas' Jenkins
The studies will have a follow up period. In the case of a dose of an inactivated virus, I'm not terribly concerned. Were it attenuated, a short follow-up would be sufficient as long as cGMP were followed in its production.
It's not a chronic medication and vaccines are remarkably safe for inactivated viruses. Assuming there is nothing novel in its synthesis, the RCT data will give you sufficient info.
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In no way is that answering like a politician. That's pretty damned clear.
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"When the Know-Nothings get control, it will read 'all men are created equal, except negroes, and foreigners, and Catholics.' When it comes to this I should prefer emigrating to some country where they make no pretense of loving liberty – to Russia, for instance, where despotism can be taken pure, and without the base alloy of hypocrisy.”--Abraham Lincoln
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