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On October 4, 2012, Amendola suffered a dislocated clavicle in the second quarter of the game versus the Arizona Cardinals.
In a rare case, instead of popping out, the clavicle popped in and came millimeters from puncturing his trachea and aorta, which could have killed him. Rams' medical staff called around the league for information but no teams had ever had players suffering a similar injury.
Amendola was anesthetized before popping the clavicle back into place. Due to the unusual nature of the injury the Rams were not certain when Amendola would return, but he was able to recover after just three weeks and recorded 11 catches for 102 yards in a hard-fought tie with the San Francisco 49ers. He finished the season with 804 total yards, including 666 yards on 63 receptions and 122 yards on 17 punt returns.
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