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The mechanical parts can actually be manufactured relatively early in Northern Europe. Probably the 1300s. Mechanical clocks were mentioned in writings as far back as 1280. The Northern Europeans had a very good grasp of mechanization based off of water mills, partly why they industrialized so quickly they had all the components figured out just need to hook up to a different power source.
The problem is something to power the engine. The earliest possible would be with steam and you would be looking at more locomotive than car at that point.
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