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Old 06-27-2016, 11:23 AM  
DaFace DaFace is offline
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Investing megathread extravaganza
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Last edited by DaFace; 02-19-2021 at 06:35 PM..
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Old 03-09-2020, 09:52 AM   #3931
MahiMike MahiMike is offline
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So why the **** is gasoline still close to $3 a gallon here in Phoenix area?

God damn thieves!
$2.01 here in FL
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Old 03-09-2020, 09:53 AM   #3932
MahiMike MahiMike is offline
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I moved my money to safety probably 10 days ago or more and I had a bunch on the sideline anyway. I'm wanting to get back in but where's the bottom? Then I need a good seven or eight year run up to retirement.
Same here.
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Old 03-09-2020, 09:54 AM   #3933
Strongside Strongside is offline
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Pulled everything I had in the S&P500 ETFs early last week, and bought back in cautiously this morning (about 1/3 of what I was in for initially.)

I'd love to tell you this might be the bottom, but this shit is unprecedented right now. A new cliff seems to appear daily.
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Old 03-09-2020, 09:59 AM   #3934
Hammock Parties Hammock Parties is online now
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Pulled everything I had in the S&P500 ETFs early last week, and bought back in cautiously this morning (about 1/3 of what I was in for initially.)

I'd love to tell you this might be the bottom, but this shit is unprecedented right now. A new cliff seems to appear daily.
easy money you rat bastard
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Old 03-09-2020, 10:18 AM   #3935
Strongside Strongside is offline
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easy money you rat bastard
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Old 03-09-2020, 11:35 AM   #3936
Halfcan Halfcan is offline
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This sounds very promising!

VANCOUVER, British Columbia, March 09, 2020 (GLOBE NEWSWIRE) -- Algernon Pharmaceuticals Inc. (CSE: AGN) (FRANKFURT: AGW) (OTCQB: AGNPF) (the “Company” or “Algernon”) a clinical stage pharmaceutical development company is pleased to announce that it has made the decision to begin production of NP-120 (Ifenprodil) with a new injectable and long acting oral release formulation, in order to be prepared for new US clinical trials for COVID-19 (coronavirus) and acute lung injury (ALI).
The decision was made after a recent independent study found that Ifenprodil significantly reduced ALI and improved survivability in an animal study with Asian H5N1 infected mice by 40%. Asian H5N1 is the most lethal form of influenza known to date with an over 50% mortality rate. This compelling data, generated via a genome wide RNAi interference approach, that lead the investigators to the identification of Ifenprodil, an NMDA receptor antagonist, has been a major contributing factor in the Company’s decision.
The Company is in negotiations with a number of manufacturers and will be announcing more details on its decision shortly.
“The Company believes strongly in the potential of Ifenprodil to treat patients who have a severe acute lung injury, including people who have various forms of respiratory infections including COVID-19 (coronavirus) and influenza,” said Christopher J. Moreau CEO of Algernon Pharmaceuticals.
Algernon has filed new intellectual property rights for NP-120 (Ifenprodil) for the treatment of respiratory diseases.
About NP-120 (Ifenprodil)
NP-120 (Ifenprodil) is an N-methyl-d-aspartate (NDMA) receptor glutamate receptor antagonist specifically targeting the NMDA-type subunit 2B (Glu2NB). Ifenprodil also exhibits agonist activity for the Sigma-1 receptor, a chaperone protein up-regulated during endoplasmic reticulum stress. Although the anti-fibrotic activity of Ifenprodil in IPF is not known, recent studies have suggested a link between both receptors and pathways associated with fibrosis.
Glutamate (Glu) is the main excitatory neurotransmitter which acts on glutamate receptors in the central nervous system (CNS) but overactivation of these receptors can cause several damages to neural cells including death. Recent studies show that the glutamate agonist N-methyl-d-aspartate (NMDA) can trigger acute lung injury (ALI). ALI is a direct and indirect injury to alveolar epithelial cells and capillary endothelial cell, causing diffuse pulmonary interstitial and alveolar edema and acute hypoxic respiration failure. ALI is characterized by reduced lung volume and compliance, and imbalance of the ventilation/perfusion ratio, inducing hypoxemia and respiratory distress and its severe stage (oxygen index <200) known as acute respiratory distress syndrome (ARDS). (1) Furthermore, pathological findings show that 64% of ARDS patients may have pulmonary fibrosis during convalescence (2).
NP-120 (Ifenprodil - brand name Cerocal) was initially developed by Sanofi in the 1990s in the French and Japanese markets for the treatment of circulatory disorders. The drug is genericized and sold in Japan.
About Algernon Pharmaceuticals Inc.
Algernon Pharmaceuticals is a clinical stage pharmaceutical development company focused on advancing its lead compounds for non–alcoholic steatohepatitis (NASH), chronic kidney disease (CKD) inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), and chronic cough.
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Old 03-09-2020, 12:17 PM   #3937
Rain Man Rain Man is online now
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We're in the running today for one of the 10 worst Dow percentage drops in history. Currently tied for the #11 spot with some random day during the Great Depression.

https://en.wikipedia.org/wiki/List_o...entage_changes
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Old 03-09-2020, 12:43 PM   #3938
displacedinMN displacedinMN is offline
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Old 03-09-2020, 12:48 PM   #3939
Hog's Gone Fishin Hog's Gone Fishin is offline
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today sucks
only if you sell and lock in that loss
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Old 03-09-2020, 12:50 PM   #3940
Hog's Gone Fishin Hog's Gone Fishin is offline
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What was it Warren Buffet said, something to the effect, "we've been through WWII, Korean War ,Vietnam, 9/11 and the stock market came back every time. This is nothing but the flu!
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Old 03-09-2020, 12:51 PM   #3941
SuperBowl4 SuperBowl4 is offline
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Old 03-09-2020, 12:53 PM   #3942
Rain Man Rain Man is online now
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only if you sell and lock in that loss
I'm riding it down and then hopefully back up again. But here's what down feels like.

via GIPHY

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Old 03-09-2020, 12:54 PM   #3943
scho63 scho63 is offline
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today sucks
How many people have been complaining that they wish they bought "XYZ" company before it ran up so much?

There are the beginnings of bargains in the market.

Also, if you were thinking of funding your Roth IRA or 401K, what a great time and at much better prices than 2 weeks ago......

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Old 03-09-2020, 01:15 PM   #3944
Hog's Gone Fishin Hog's Gone Fishin is offline
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I went ahead and borrowed 10K and bought oil.
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Old 03-09-2020, 01:23 PM   #3945
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I went ahead and borrowed 10K and bought oil.
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