Quote:
Originally Posted by dwwataz
They actually started me on Tylenol 3, then 4, before being bumped to hydrocodone 5, 7.5, and ultimately the 10s. Even though the opiate dosage is higher in the hydrocodone, I felt substantially more lethargic on the codeine
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There's a chance you could be an ultra-rapid metabolizer of CYP 2D6. Codeine is a prodrug that is in converted to morphine. A small subset of the population has more of those specific enzymes than others. If so, a "normal" dose of codeine can actually be much higher for the person in question.
This is why codeine is not given to children anymore.
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"When the Know-Nothings get control, it will read 'all men are created equal, except negroes, and foreigners, and Catholics.' When it comes to this I should prefer emigrating to some country where they make no pretense of loving liberty – to Russia, for instance, where despotism can be taken pure, and without the base alloy of hypocrisy.”--Abraham Lincoln
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