Lion's Mane Mushrooms and Nootropica

['Hamas' Jenkins]

I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.

[Marcellus]

Originally Posted by 'Hamas' Jenkins

I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.

Are you saying that drinking protein shakes doesn't do you any good as a dietary supplement or is that not part of the structure/function purpose you are talking about? I assume you are talking about the new craze of people taking peptides in oral form for things like improving HGH levels etc...?

['Hamas' Jenkins]

Originally Posted by Marcellus

Are you saying that drinking protein shakes doesn't do you any good as a dietary supplement or is that not part of the structure/function purpose you are talking about? I assume you are talking about the new craze of people taking peptides in oral form for things like improving HGH levels etc...?

Structure/function meaning medicinal benefits, not nutrition. It's why supplements aren't regulated by the FDA. They can't make claims about structure or function. Protein shakes will give you protein. 5-HT is serotonin, but when taken orally, it undergoes confirmational changes as it is metabolized, which alters its affinity for its receptors. When you take it, you're paying a lot of money for very little amino acid.

[Marcellus]

Originally Posted by 'Hamas' Jenkins

Structure/function meaning medicinal benefits, not nutrition. It's why supplements aren't regulated by the FDA. They can't make claims about structure or function. Protein shakes will give you protein. 5-HT is serotonin, but when taken orally, it undergoes confirmational changes as it is metabolized, which alters its affinity for its receptors. When you take it, you're paying a lot of money for very little amino acid.

Ok that's what I thought you meant. I noticed a lot of companies are trying to sell oral peptides now but everything I have read says they have to be injected to be effective.

Oral serotonin not being effective is new info for me though.

In a nutshell what you are saying is any amino acid based compound isn't effective taken orally (if taken for functional purposes).

['Hamas' Jenkins]

Originally Posted by Marcellus

Ok that's what I thought you meant. I noticed a lot of companies are trying to sell oral peptides now but everything I have read says they have to be injected to be effective.

Oral serotonin not being effective is new info for me though.

In a nutshell what you are saying is any amino acid based compound isn't effective taken orally (if taken for functional purposes).

In about 99.5% of the cases, yes. That's why treatments for depression work on serotonin reuptake by neurotransmitters. You can't ingest more serotonin, but if you prevent the neurotransmitters from hoovering back up, you allow the existing serotonin to exert its effects over a longer period which enhances mood.

Bioavailability is key.

[penguinz]

Originally Posted by 'Hamas' Jenkins

I'm going to give everyone some free advice: any amino acid or protein supplement you take orally for a structure/function purpose is a complete waste of money. The acidic environment of the stomach will protonate sites on the amino acids and change their conformational structure. That's why monoclonal antibodies are injectable.

Not 100% true. BPC-157 has been proven to aid in treatment and prevention of ulcers and other digestive track issues when taken orally.

[BWillie]

Originally Posted by penguinz

Not 100% true. BPC-157 has been proven to aid in treatment and prevention of ulcers and other digestive track issues when taken orally.

Almost every doctor Ive ever talked to think Nootropics is a bunch of hogwash. I assume most of it is but after taking a medical probiotic and seeing how theanine can work there has to be some benefits.

[penguinz]

Originally Posted by BWillie

Almost every doctor Ive ever talked to think Nootropics is a bunch of hogwash. I assume most of it is but after taking a medical probiotic and seeing how theanine can work there has to be some benefits.

BPC-157 isn't a nootropic. I was just using it as an example of an AA that is gastric stable and can be taken effectively orally.

Probably helps that BPC-157 is made naturally in the gastric lining.

[Wisconsin_Chief]

Originally Posted by BWillie

Almost every doctor Ive ever talked to think Nootropics is a bunch of hogwash. I assume most of it is but after taking a medical probiotic and seeing how theanine can work there has to be some benefits.

They are definitely not hogwash, the long term safety was my biggest concern. I tinkered around about 7-8 years ago with bulk powder and making my own capsules, I absolutely noticed a huge difference. Adrafinil was my favorite, totally legal and your liver converts it to Modofinil. I was really into it for about a year, but then I changed to a Keto/Carnivore lifestyle and my brain fog basically vanished, so I have no need for it anymore.

They definitely helped me in my early days of sales, that’s for sure. If you have brain fog issues, they are absolutely worth exploring. Just don’t cheap out on what you buy, because you get what you pay for when it comes to this stuff.

[BWillie]

Originally Posted by Wisconsin_Chief

They are definitely not hogwash, the long term safety was my biggest concern. I tinkered around about 7-8 years ago with bulk powder and making my own capsules, I absolutely noticed a huge difference. Adrafinil was my favorite, totally legal and your liver converts it to Modofinil. I was really into it for about a year, but then I changed to a Keto/Carnivore lifestyle and my brain fog basically vanished, so I have no need for it anymore.

They definitely helped me in my early days of sales, that’s for sure. If you have brain fog issues, they are absolutely worth exploring. Just don’t cheap out on what you buy, because you get what you pay for when it comes to this stuff.

Where did you get the Adrafinil? I feel like taking that instead of chugging two Red Bulls a day would be more healthy.

Never thought about making your own capsules. I'm sure powder is much cheaper. Was it a big pain in the ass or pretty easy process?

['Hamas' Jenkins]

Originally Posted by penguinz

Not 100% true. BPC-157 has been proven to aid in treatment and prevention of ulcers and other digestive track issues when taken orally.

Okay, cool. Show me the study.

[penguinz]

Originally Posted by 'Hamas' Jenkins

Okay, cool. Show me the study.

https://pubmed.ncbi.nlm.nih.gov/21548867/

[loochy]

Originally Posted by penguinz

https://pubmed.ncbi.nlm.nih.gov/21548867/

I hate that stupid ass emoji that ruins so many links.


Mods, can we change the code for that one?

[Bowser]

Originally Posted by loochy

I hate that stupid ass emoji that ruins so many links.


Mods, can we change the code for that one?

I see the emoji as well but still was able to get to the link

['Hamas' Jenkins]

Originally Posted by penguinz

https://pubmed.ncbi.nlm.nih.gov/21548867/

That was a study conducted in rats and made no reference to enteral dosing.