***NON-POLITICAL COVID-19 Discussion Thread***

[JakeF]

A couple of reminders...

Originally Posted by Bwana

Once again, don't come in this thread with some kind of political agenda, or you will be shown the door. If you want to go that route, there is a thread about this in DC.

Originally Posted by Dartgod

People, there is a lot of good information in this thread, let's try to keep the petty bickering to a minimum.

We all have varying opinions about the impact of this, the numbers, etc. We will all never agree with each other. But we can all keep it civil.

Thanks!

Click here for the original OP:

Spoiler!

Apparently the CoronaVirus can survive on a inanimate objects, such as door knobs, for 9 days.

California coronavirus case could be first spread within U.S. community, CDC says
By SOUMYA KARLAMANGLA, JACLYN COSGROVE
FEB. 26, 2020 8:04 PM

The Centers for Disease Control and Prevention is investigating what could be the first case of novel coronavirus in the United States involving a patient in California who neither recently traveled out of the country nor was in contact with someone who did.

“At this time, the patient’s exposure is unknown. It’s possible this could be an instance of community spread of COVID-19, which would be the first time this has happened in the United States,” the CDC said in a statement. “Community spread means spread of an illness for which the source of infection is unknown. It’s also possible, however, that the patient may have been exposed to a returned traveler who was infected.”

The individual is a resident of Solano County and is receiving medical care in Sacramento County, according to the state Department of Public Health.

The CDC said the “case was detected through the U.S. public health system — picked up by astute clinicians.”

Officials at UC Davis Medical Center expanded on what the federal agency might have meant by that in an email sent Wednesday, as reported by the Davis Enterprise newspaper.

The patient arrived at UC Davis Medical Center from another hospital Feb. 19 and “had already been intubated, was on a ventilator, and given droplet protection orders because of an undiagnosed and suspected viral condition,” according to an email sent by UC Davis officials that was obtained by the Davis Enterprise.

The staff at UC Davis requested COVID-19 testing by the CDC, but because the patient didn’t fit the CDC’s existing criteria for the virus, a test wasn’t immediately administered, according to the email. The CDC then ordered the test Sunday, and results were announced Wednesday. Hospital administrators reportedly said in the email that despite these issues, there has been minimal exposure at the hospital because of safety protocols they have in place.

A UC Davis Health spokesperson declined Wednesday evening to share the email with The Times.

Since Feb. 2, more than 8,400 returning travelers from China have entered California, according to the state health department. They have been advised to self-quarantine for 14 days and limit interactions with others as much as possible, officials said.

“This is a new virus, and while we are still learning about it, there is a lot we already know,” Dr. Sonia Angell, director of the California Department of Public Health, said in a statement. “We have been anticipating the potential for such a case in the U.S., and given our close familial, social and business relationships with China, it is not unexpected that the first case in the U.S. would be in California.”

It is not clear how the person became infected, but public health workers could not identify any contacts with people who had traveled to China or other areas where the virus is widespread. That raises concern that the virus is spreading in the United States, creating a challenge for public health officials, experts say.

“It’s the first signal that we could be having silent transmission in the community,” said Lawrence Gostin, director of the World Health Organization Collaborating Center on National and Global Health Law. “It probably means there are many more cases out there, and it probably means this individual has infected others, and now it’s a race to try to find out who that person has infected.”

On Tuesday, the CDC offered its most serious warning to date that the United States should expect and prepare for the coronavirus to become a more widespread health issue.

“Ultimately, we expect we will see coronavirus spread in this country,” said Nancy Messonnier, director of the CDC’s National Center for Immunization and Respiratory Diseases. “It’s not so much a question of if, but a question of when.”

According to the CDC’s latest count Wednesday morning, 59 U.S. residents have tested positive for the new strain of coronavirus — 42 of whom are repatriated citizens from a Diamond Princess cruise. That number has grown by two since Messonnier’s last count Tuesday, although the CDC was not immediately available to offer details on the additional cases.

More than 82,000 cases of coronavirus have been reported globally, and more than 2,700 people have died, with the majority in mainland China, the epicenter of the outbreak.

But public health leaders have repeatedly reminded residents that the health risk from the novel coronavirus to the general public remains low.

“While COVID-19 has a high transmission rate, it has a low mortality rate,” the state Department of Public Health said in a statement Wednesday. “From the international data we have, of those who have tested positive for COVID-19, approximately 80% do not exhibit symptoms that would require hospitalization. There have been no confirmed deaths related to COVID-19 in the United States to date.”

CDC officials have also warned that although the virus is likely to spread in U.S. communities, the flu still poses a greater risk.

Gostin said the news of potential silent transmission does not eliminate the possibility of containing the virus in the U.S. and preventing an outbreak.

“There are few enough cases that we should at least try,” he said. “Most of us are not optimistic that that will be successful, but we’re still in the position to try.”

[Chief Roundup]

Originally Posted by jd1020

Not sure what exactly can be done. Maybe require them to take a test and if they come back negative then no harm no foul.

Arrest them every one for leaving the order in NY and ship them back or detain them in jail.

[O.city]

Hamas what do you know about favipiravir?

[jd1020]

Originally Posted by Chief Roundup

Arrest them every one for leaving the order in NY and ship them back or detain them in jail.

Was unaware NY was quarantined.

[Chief Roundup]

Originally Posted by D2112

Right now it’s a battle between people with common sense, and without.

Yes and as more and more people panic and leave the areas they live in, yes I am looking at you NYC, because the powers to be will not do what is necessary to contain this virus people will start dying from "lead".

[Chief Roundup]

Originally Posted by jd1020

Was unaware NY was quarantined.

Shelter in place order.

[DaFace]

Originally Posted by Chief Roundup

Arrest them every one for leaving the order in NY and ship them back or detain them in jail.

It's a little hard when the law in question is the Constitution.

[jd1020]

Originally Posted by Chief Roundup

Shelter in place order.

That's not a full blown quarantine. Just like every other state with a stay at home order it's not a ban on travel/leaving your home.

[Chief Roundup]

Originally Posted by DaFace

It's a little hard when the law in question is the Constitution.

Is that going to lead to a question of "scared for the safety of myself and my families safety"?

[jd1020]

Originally Posted by Chief Roundup

Is that going to lead to a question of "scared for the safety of myself and my families safety"?

Does your family not practice standard sanitation?

[TLO]

Originally Posted by O.city

Hamas what do you know about favipiravir?

Dr. Google says it sounds promising, but it's in Japan primarily.

Are the cloriquine trials not going well? Doesn't seem as though we've been hearing much about them.

[Chief Roundup]

Originally Posted by jd1020

Does your family not practice standard sanitation?

It will not be my cousins that still live in the area, the rest of my family lives 45 minutes away, that might take this too far.

['Hamas' Jenkins]

Originally Posted by O.city

Hamas what do you know about favipiravir?

Not much more than you do, probably. Upon briefly reading an article, it seems that it may not have great activity in human respiratory cells, which you'd obviously want when fighting a virus attacking alveoli. That's something that a lot of providers don't consider--drugs often have vastly different penetration depending upon what organ you are speaking of.

There is a powerful antibiotic that can be used for MRSA called Daptomycin, but you can't use it in lung infections because it is inactivated by pulmonary surfactant. Cefpodoxime is a good antibiotic, but it doesn't achieve good concentration in the urine, so it's not good against UTIs, etc.

There is a Chinese study where it performed better than Kaletra with interferon alpha, but is that due to an interaction between Kaletra and interferon or is favipravir truly better? It was an open-label study, both Kaletra and interferon can be hepatotoxic (although favipravir is also hepatotoxic). It's just too hard to tell.

Watching people's reactions to this reminds me of reading about early therapies thought to work against HIV. Patients (including Rock Hudson) traveled from all over the world to go to Paris to receive a drug called HPA-23, doctors actually conducted trials with a drug that was not legal to import in the US called trichosanthin (which was an extract from a Chinese root). In the end, one compound developed in the 60s was effective (AZT was a failed cancer drug developed at NIH), but it was years before truly effective therapies emerged.

[Donger]

Originally Posted by RINGLEADER

NY has more cases today than any other country on planet Earth. Given how bad it’s been in Italy and Spain (who have never gotten as high in daily new infections as NY today) that’s just crazy.

Yep. Just stunning figures. I wish NYC had taken it more seriously. Maybe next time.

[O.city]

Originally Posted by 'Hamas' Jenkins

Not much more than you do, probably. Upon briefly reading an article, it seems that it may not have great activity in human respiratory cells, which you'd obviously want when fighting a virus attacking alveoli. That's something that a lot of providers don't consider--drugs often have vastly different penetration depending upon what organ you are speaking of.

There is a powerful antibiotic that can be used for MRSA called Daptomycin, but you can't use it in lung infections because it is inactivated by pulmonary surfactant. Cefpodoxime is a good antibiotic, but it doesn't achieve good concentration in the urine, so it's not good against UTIs, etc.

There is a Chinese study where it performed better than Kaletra with interferon alpha, but is that due to an interaction between Kaletra and interferon or is favipravir truly better? It was an open-label study, both Kaletra and interferon can be hepatotoxic (although favipravir is also hepatotoxic). It's just too hard to tell.

Watching people's reactions to this reminds me of reading about early therapies thought to work against HIV. Patients (including Rock Hudson) traveled from all over the world to go to Paris to receive a drug called HPA-23, doctors actually conducted trials with a drug that was not legal to import in the US called trichosanthin (which was an extract from a Chinese root). In the end, one compound developed in the 60s was effective (AZT was a failed cancer drug developed at NIH), but it was years before truly effective therapies emerged.

They had some success with it in China which you know if they’re complimenting the Japanese it must have worked

Read one study that it had really good success with mild and moderate cases which would make some sense in regards to the respiratory issue

[Bob Dole]

You quarantine sick people to keep them away from the healthy. This is house arrest. Call shit what it is.