***NON-POLITICAL COVID-19 Discussion Thread***

[JakeF]

A couple of reminders...

Originally Posted by Bwana

Once again, don't come in this thread with some kind of political agenda, or you will be shown the door. If you want to go that route, there is a thread about this in DC.

Originally Posted by Dartgod

People, there is a lot of good information in this thread, let's try to keep the petty bickering to a minimum.

We all have varying opinions about the impact of this, the numbers, etc. We will all never agree with each other. But we can all keep it civil.

Thanks!

Click here for the original OP:

Spoiler!

Apparently the CoronaVirus can survive on a inanimate objects, such as door knobs, for 9 days.

California coronavirus case could be first spread within U.S. community, CDC says
By SOUMYA KARLAMANGLA, JACLYN COSGROVE
FEB. 26, 2020 8:04 PM

The Centers for Disease Control and Prevention is investigating what could be the first case of novel coronavirus in the United States involving a patient in California who neither recently traveled out of the country nor was in contact with someone who did.

“At this time, the patient’s exposure is unknown. It’s possible this could be an instance of community spread of COVID-19, which would be the first time this has happened in the United States,” the CDC said in a statement. “Community spread means spread of an illness for which the source of infection is unknown. It’s also possible, however, that the patient may have been exposed to a returned traveler who was infected.”

The individual is a resident of Solano County and is receiving medical care in Sacramento County, according to the state Department of Public Health.

The CDC said the “case was detected through the U.S. public health system — picked up by astute clinicians.”

Officials at UC Davis Medical Center expanded on what the federal agency might have meant by that in an email sent Wednesday, as reported by the Davis Enterprise newspaper.

The patient arrived at UC Davis Medical Center from another hospital Feb. 19 and “had already been intubated, was on a ventilator, and given droplet protection orders because of an undiagnosed and suspected viral condition,” according to an email sent by UC Davis officials that was obtained by the Davis Enterprise.

The staff at UC Davis requested COVID-19 testing by the CDC, but because the patient didn’t fit the CDC’s existing criteria for the virus, a test wasn’t immediately administered, according to the email. The CDC then ordered the test Sunday, and results were announced Wednesday. Hospital administrators reportedly said in the email that despite these issues, there has been minimal exposure at the hospital because of safety protocols they have in place.

A UC Davis Health spokesperson declined Wednesday evening to share the email with The Times.

Since Feb. 2, more than 8,400 returning travelers from China have entered California, according to the state health department. They have been advised to self-quarantine for 14 days and limit interactions with others as much as possible, officials said.

“This is a new virus, and while we are still learning about it, there is a lot we already know,” Dr. Sonia Angell, director of the California Department of Public Health, said in a statement. “We have been anticipating the potential for such a case in the U.S., and given our close familial, social and business relationships with China, it is not unexpected that the first case in the U.S. would be in California.”

It is not clear how the person became infected, but public health workers could not identify any contacts with people who had traveled to China or other areas where the virus is widespread. That raises concern that the virus is spreading in the United States, creating a challenge for public health officials, experts say.

“It’s the first signal that we could be having silent transmission in the community,” said Lawrence Gostin, director of the World Health Organization Collaborating Center on National and Global Health Law. “It probably means there are many more cases out there, and it probably means this individual has infected others, and now it’s a race to try to find out who that person has infected.”

On Tuesday, the CDC offered its most serious warning to date that the United States should expect and prepare for the coronavirus to become a more widespread health issue.

“Ultimately, we expect we will see coronavirus spread in this country,” said Nancy Messonnier, director of the CDC’s National Center for Immunization and Respiratory Diseases. “It’s not so much a question of if, but a question of when.”

According to the CDC’s latest count Wednesday morning, 59 U.S. residents have tested positive for the new strain of coronavirus — 42 of whom are repatriated citizens from a Diamond Princess cruise. That number has grown by two since Messonnier’s last count Tuesday, although the CDC was not immediately available to offer details on the additional cases.

More than 82,000 cases of coronavirus have been reported globally, and more than 2,700 people have died, with the majority in mainland China, the epicenter of the outbreak.

But public health leaders have repeatedly reminded residents that the health risk from the novel coronavirus to the general public remains low.

“While COVID-19 has a high transmission rate, it has a low mortality rate,” the state Department of Public Health said in a statement Wednesday. “From the international data we have, of those who have tested positive for COVID-19, approximately 80% do not exhibit symptoms that would require hospitalization. There have been no confirmed deaths related to COVID-19 in the United States to date.”

CDC officials have also warned that although the virus is likely to spread in U.S. communities, the flu still poses a greater risk.

Gostin said the news of potential silent transmission does not eliminate the possibility of containing the virus in the U.S. and preventing an outbreak.

“There are few enough cases that we should at least try,” he said. “Most of us are not optimistic that that will be successful, but we’re still in the position to try.”

[philfree]

It's looking like my want for a negative test is double crossing me. I appreciate the feedback.

[Skyy God]

Great job Howell County!

https://www.ksmu.org/post/covid-19-s...ences#stream/0

[O.city]

Yeah that’s down around where I grew up. They definitely didn’t take it very serious early.

Now it’s hitting extremely hard down there

[Skyy God]

Originally Posted by O.city

Yeah that’s down around where I grew up. They definitely didn’t take it very serious early.

Now it’s hitting extremely hard down there

I was born there.

Zero percent surprised.

[petegz28]

JoCo officials don’t know how many COVID tests may be false positives
https://sentinelksmo.org/joco-offici...jET9jrdIWE8WzM

[petegz28]

Schoolchildren Seem Unlikely to Fuel Coronavirus Surges, Scientists Say

https://www.nytimes.com/2020/10/22/h...6VdtDOpLGjroew

[Demonpenz]

well at-least I won't have to listen to WW2 stories anymore when eating at the mission perkins

[O.city]

83k cases today. The Midwest spike is happening pretty hard right now.

[TLO]

Originally Posted by O.city

83k cases today. The Midwest spike is happening pretty hard right now.

The Midwest is definitely being hit the hardest, but there's areas so over the country seeing a big increase in cases.

['Hamas' Jenkins]

Updates on therapeutics:

--Convalescent plasma failed a Phase II RCT in India
--Remdesivir was given FDA approval for all patients over 40kg based upon trials of 1000 patients each, but the information from SOLIDARITY did not demonstrate the same benefit with a larger cohort (~2700 patients)
--IDSA guidelines recommend remdesivir use for patients with moderate-severe COVID, with five day courses for patients not requiring ventilation, and 10-day courses for patients on mechanical vents or ECMO
--Dexamethasone is recommended for patients with moderate to severe disease
--Hydroxychloroquine is not recommended
--Hydroxychloroquine and azithromycin are not recommended
--Tocilizumab is not recommended outside of a clinical trial
--Kaletra is not recommended outside of a clinical trial

[TLO]

Originally Posted by 'Hamas' Jenkins

Updates on therapeutics:

--Convalescent plasma failed a Phase II RCT in India
--Remdesivir was given FDA approval for all patients over 40kg based upon trials of 1000 patients each, but the information from SOLIDARITY did not demonstrate the same benefit with a larger cohort (~2700 patients)
--IDSA guidelines recommend remdesivir use for patients with moderate-severe COVID, with five day courses for patients not requiring ventilation, and 10-day courses for patients on mechanical vents or ECMO
--Dexamethasone is recommended for patients with moderate to severe disease
--Hydroxychloroquine is not recommended
--Hydroxychloroquine and azithromycin are not recommended
--Tocilizumab is not recommended outside of a clinical trial
--Kaletra is not recommended outside of a clinical trial

That's a whole lot of disappointment.

[TLO]

Anything in clinical trials that DOES look promising?

['Hamas' Jenkins]

Originally Posted by TLO

That's a whole lot of disappointment.

From the outside, I understand your disappointment, but consider that it took six years for any FDA-approved therapy for HIV, Hep C has only been realistically curable in the last decade, and there is still no treatment for many viral infections beyond supportive care.

With that said, the demonstrated mortality benefit from dexamethasone and the potential morbidity benefit from remdesivir are promising and are one of the reasons why death rates are less severe than the spring despite an uptick in confirmed infections.

A magic bullet was always incredibly unlikely given the nature of viral infections (vs. bacteria or fungal colonization). The Oxford vaccine trial seems to be progressing well. I wouldn't despair.

[TLO]

Originally Posted by 'Hamas' Jenkins

From the outside, I understand your disappointment, but consider that it took six years for any FDA-approved therapy for HIV, Hep C has only been realistically curable in the last decade, and there is still no treatment for many viral infections beyond supportive care.

With that said, the demonstrated mortality benefit from dexamethasone and the potential morbidity benefit from remdesivir are promising and are one of the reasons why death rates are less severe than the spring despite an uptick in confirmed infections.

A magic bullet was always incredibly unlikely given the nature of viral infections (vs. bacteria or fungal colonization). The Oxford vaccine trial seems to be progressing well. I wouldn't despair.

That's a very reasonable way to look at things. Thank you for your input. As always, it's much appreciated.

[O.city]

Viral therapeutics are just a bitch to make. There’s a reason those little ****ers are so hard to deal with.

The mAb are still the beat option I think but they’re hard to make. Just gonna have to grit thru and hold on right for another couple months