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#39586 |
In Search of a Life
Join Date: Jul 2009
Casino cash: $-625936
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I’m skeptical but that would be awesome
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Posts: 84,191
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#39587 | |
Supporter
Join Date: Jun 2002
Casino cash: $-640286
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Posts: 2,101
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#39588 |
Veteran
Join Date: Jan 2020
Location: Missouri
Casino cash: $8550400
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NIH release on an early frontrunner vaccine
https://www.nih.gov/news-events/news...mmune-response
An investigational vaccine, mRNA-1273, designed to protect against SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), was generally well tolerated and prompted neutralizing antibody activity in healthy adults, according to interim results published online today in The New England Journal of Medicine. The ongoing Phase 1 trial is supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The experimental vaccine is being co-developed by researchers at NIAID and at Moderna, Inc. of Cambridge, Massachusetts. Manufactured by Moderna, mRNA-1273 is designed to induce neutralizing antibodies directed at a portion of the coronavirus “spike” protein, which the virus uses to bind to and enter human cells. The trial was led by Lisa A. Jackson, M.D., MPH, of Kaiser Permanente Washington Health Research Institute in Seattle, where the first participant received the candidate vaccine on March 16. This interim report details the initial findings from the first 45 participants ages 18 to 55 years enrolled at the study sites in Seattle and at Emory University in Atlanta. Three groups of 15 participants received two intramuscular injections, 28 days apart, of either 25, 100 or 250 micrograms (mcg) of the investigational vaccine. All the participants received one injection; 42 received both scheduled injections. In April, the trial was expanded to enroll adults older than age 55 years; it now has 120 participants. However, the newly published results cover the 18 to 55-year age group only. Regarding safety, no serious adverse events were reported. More than half of the participants reported fatigue, headache, chills, myalgia or pain at the injection site. Systemic adverse events were more common following the second vaccination and in those who received the highest vaccine dose. Data on side effects and immune responses at various vaccine dosages informed the doses used or planned for use in the Phase 2 and 3 clinical trials of the investigational vaccine. The interim analysis includes results of tests measuring levels of vaccine-induced neutralizing activity through day 43 after the second injection. Two doses of vaccine prompted high levels of neutralizing antibody activity that were above the average values seen in convalescent sera obtained from persons with confirmed COVID-19 disease. A Phase 2 clinical trial of mRNA-1273, sponsored by Moderna, began enrollment in late May. Plans are underway to launch a Phase 3 efficacy trial in July 2020. |
Posts: 3,159
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#39589 |
Supporter
Join Date: Feb 2005
Location: Olathe, Ks
Casino cash: $-995873
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I think we are in a very crucial moment on how we approach this and the data is what people need to focus on. Prior to this recent surge in cases the peak date of cases was April 24th. The peak date for deaths was April 21st. Ironically deaths peaked before cases.
That being said we have been seeing cases rise since June 13th. We have been setting new records for cases since June 25th. Thankfully deaths have not risen anywhere close tot he pace that cases are. The other day we ticked over 1,000 deaths for the first time in several weeks but even that was only by 2 or 3 deaths. Point being we are not seeing a NY style outcome thus far. While cases going up is definitely cause for concern we are not seeing the previous outcome repeat itself. At least for now. |
Posts: 132,414
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#39590 |
In Search of a Life
Join Date: Jul 2009
Casino cash: $-625936
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I’m guessing if we’d have been testing before like we are now, we’d have seen the cases go up like this in New York
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Posts: 84,191
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#39591 |
Supporter
Join Date: Feb 2005
Location: Olathe, Ks
Casino cash: $-995873
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I'd like to think so but every time you hear someone say that there is someone that says cases aren't going up because of more testing. Seems prior to that we all heard as testing increases so will cases but as that has come to fruition the narrative has changed a bit.
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Posts: 132,414
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#39592 |
In Search of a Life
Join Date: Jul 2009
Casino cash: $-625936
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For the deaths to be what they are or were in New York there must have been a shot load of missed cases
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Posts: 84,191
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#39593 |
Supporter
Join Date: Feb 2005
Location: Olathe, Ks
Casino cash: $-995873
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Could be. Or we have learned how to treat things better and can prevent them. I'd like to think more of the latter honestly. Also remember that almost half of the deaths in NY were induced by bad decisions like sending Covid patients into nursing homes and then things like improper circulation in hospitals that contributed to spread.
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Posts: 132,414
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#39594 | |
Please squeeze
Join Date: Jul 2003
Location: Clinton, MO
Casino cash: $214644
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Quote:
They were only doing like 10-20k tests per day or less during the peak of their outbreak. Florida is doing 60-80k daily and their positive rate is 18%. NY was flying blind just like the rest of the country was during the spring because we weren't prepared. So yeah they missed a shit ton of cases and deaths. |
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Posts: 67,107
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#39595 |
Please squeeze
Join Date: Jul 2003
Location: Clinton, MO
Casino cash: $214644
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And you can look at individual state testing data here
https://coronavirus.jhu.edu/testing/...tates/new-york |
Posts: 67,107
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#39596 |
Please squeeze
Join Date: Jul 2003
Location: Clinton, MO
Casino cash: $214644
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Posts: 67,107
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#39597 |
In Search of a Life
Join Date: Jul 2009
Casino cash: $-625936
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Posts: 84,191
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#39598 |
"Think BOOM!"
Join Date: Nov 2003
Location: 33.675° N 106.475° W
Casino cash: $6829900
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DENVER (CBS4) – Gov. Jared Polis issued a statewide mask mandate on Thursday as the number of COVID-19 cases are showing what he called a “significant uptick.” The governor has spent months urging people to wear masks in order to prevent the further spread of coronavirus, and now he has issued an executive order that will go into effect on Friday which requires it.
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I think the young people enjoy it when I "get down," verbally, don't you? |
Posts: 191,117
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#39599 | |
I love your mom
Join Date: Feb 2020
Location: Sturgeon Falls, Ontario
Casino cash: $-935043
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Posts: 7,778
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#39600 |
"Think BOOM!"
Join Date: Nov 2003
Location: 33.675° N 106.475° W
Casino cash: $6829900
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Has anyone heard of any reports of commercial aircraft being the source of any outbreaks, or super spread events?
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I think the young people enjoy it when I "get down," verbally, don't you? |
Posts: 191,117
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